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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTRA2
All Species:
28.18
Human Site:
S277
Identified Species:
62
UniProt:
O43464
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43464
NP_037379.1
458
48841
S277
I
T
S
G
I
V
S
S
A
Q
R
P
A
R
D
Chimpanzee
Pan troglodytes
XP_508084
598
64926
T417
V
T
T
G
I
V
S
T
T
Q
R
G
G
K
E
Rhesus Macaque
Macaca mulatta
XP_001110803
458
48732
S277
I
T
S
G
I
V
S
S
A
Q
R
P
A
R
D
Dog
Lupus familis
XP_532992
199
21668
Y35
L
P
Q
T
N
V
E
Y
I
Q
T
D
A
A
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9JIY5
458
49330
S277
I
T
S
G
I
V
S
S
A
Q
R
P
A
R
D
Rat
Rattus norvegicus
NP_001100069
458
49076
S277
I
T
S
G
I
V
S
S
A
Q
R
P
A
R
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_420813
466
50374
T289
V
T
T
G
I
V
S
T
A
Q
R
D
G
K
E
Frog
Xenopus laevis
NP_001088796
457
48812
T276
V
T
T
G
I
V
S
T
A
Q
R
G
G
K
E
Zebra Danio
Brachydanio rerio
XP_001339411
294
31781
I130
S
N
S
N
M
D
Y
I
Q
T
D
A
T
I
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFJ3
422
45981
Y254
L
R
N
R
D
I
N
Y
L
Q
T
D
A
A
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q3E6S8
459
49256
C282
V
T
A
G
I
V
S
C
V
D
R
K
S
S
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
38.9
99.1
41.7
N.A.
84.9
87.3
N.A.
N.A.
40.9
41
43.6
N.A.
42.3
N.A.
N.A.
N.A.
Protein Similarity:
100
52.5
99.1
42.5
N.A.
89.3
91.4
N.A.
N.A.
59.4
59.1
54.3
N.A.
59.3
N.A.
N.A.
N.A.
P-Site Identity:
100
46.6
100
20
N.A.
100
100
N.A.
N.A.
53.3
53.3
13.3
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
80
100
26.6
N.A.
100
100
N.A.
N.A.
86.6
86.6
20
N.A.
40
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.7
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
0
0
55
0
0
10
55
19
0
% A
% Cys:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
10
0
0
0
10
10
28
0
0
55
% D
% Glu:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
28
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
73
0
0
0
0
0
0
0
19
28
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
37
0
0
0
73
10
0
10
10
0
0
0
0
10
19
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
10
0
28
0
% K
% Leu:
19
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% L
% Met:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
10
10
10
0
10
0
0
0
0
0
0
0
0
% N
% Pro:
0
10
0
0
0
0
0
0
0
0
0
37
0
0
0
% P
% Gln:
0
0
10
0
0
0
0
0
10
82
0
0
0
0
0
% Q
% Arg:
0
10
0
10
0
0
0
0
0
0
73
0
0
37
0
% R
% Ser:
10
0
46
0
0
0
73
37
0
0
0
0
10
10
0
% S
% Thr:
0
73
28
10
0
0
0
28
10
10
19
0
10
0
0
% T
% Val:
37
0
0
0
0
82
0
0
10
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
19
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _